Long Non-Coding RNAs: Challenging the Protein-Centric View of Gene Regulation
Thousands of RNA transcripts that encode no protein are rewriting the rules of gene regulation
Bacterial Immune Memory: How CRISPR Systems Store and Recall Pathogen Encounters
How bacteria capture viral DNA fragments and forge them into heritable weapons of sequence-specific immune defense
Synthetic Minimal Genomes: What We Learn by Building Life From Scratch
Stripping genomes to their bare essentials reveals both life's minimal requirements and the vast terrain of biological functions we cannot yet explain.
Nonsense-Mediated Decay: How Cells Eliminate Defective Transcripts Before They Cause Harm
The surveillance system that destroys defective mRNAs doubles as a gene expression regulator—and a therapeutic target
Viral Integration Sites: How Retroviruses Choose Where to Insert Their Genomes
How viral enzymes navigate chromatin landscapes to permanently inscribe themselves into host genomes—and what this means for gene therapy safety
Chromosome Segregation Fidelity: Why Cells Rarely Lose or Gain Chromosomes
The molecular machinery that counts chromosomes and halts division until every one is properly attached
Recombination Hotspots: Why Genetic Crossing Over Occurs at Specific Locations
The molecular address system that directs chromosome crossing over—and the evolutionary paradox that forces it to constantly relocate
Telomere Biology: The Molecular Clock Limiting Cell Division
How chromosome ends encode a countdown that governs cellular lifespan and cancer immortality
The Ribosome as a Regulatory Hub: How Translation Control Shapes Cellular Responses
Inside the molecular machine that doesn't just read genetic instructions—it interprets them based on cellular context
Transcription Factor Binding Specificity: How Proteins Read DNA Sequence
Three layers of molecular logic determine which DNA sequences actually get read in living cells
The Codon Bias Code: How Synonymous Mutations Shape Protein Expression and Function
Synonymous codons aren't silent—they encode translation speed, mRNA survival, and protein folding into the DNA sequence itself.
Gene Drive Technology: Engineering Inheritance to Spread Genetic Modifications
Self-propagating genetic systems that subvert Mendelian inheritance could eliminate disease vectors—or spread beyond all boundaries.
mRNA Vaccines Explained: How Nucleotide Modifications Solved the Immunogenicity Problem
How decades of RNA immunobiology research enabled the chemical modifications and delivery systems that transformed messenger RNA into programmable medicine.
CRISPR Beyond Cutting: How Base Editors Rewrite DNA One Letter at a Time
Beyond molecular scissors: how base editors perform direct chemical surgery on individual nucleotides without breaking DNA strands
Splicing Decisions: How a Single Gene Produces Multiple Proteins Through Alternative Processing
Understanding how cells select among splicing possibilities reveals disease mechanisms and enables therapeutic rewriting of genetic instructions
The Hidden Logic of Gene Regulation: How Enhancers Find Their Target Promoters
Exploring how three-dimensional genome architecture, phase-separated condensates, and enhancer syntax create the precise regulatory wiring that determines which genes activate in which cells.
Why Your DNA Repair Machinery Determines Cancer Risk More Than Mutations Themselves
Your cells sustain thousands of DNA lesions daily—whether they become cancer depends on repair machinery efficiency, not damage accumulation alone.
Why Most Genetic Variants Have No Effect: The Buffering Capacity of Biological Systems
Your genome contains millions of variants, yet biological redundancy, molecular chaperones, and threshold effects ensure most of them never matter.
Epigenetic Memory: How Cells Remember Their Identity Without Changing DNA Sequence
Discover how cells preserve their identity across divisions through chromatin inheritance, methylation maintenance, and the barriers these create for reprogramming technologies.
Transposons: The Selfish DNA Elements That Shaped Our Genome Architecture
How ancient genetic parasites colonized half your DNA and became indispensable architects of immune function, pregnancy, and gene regulation.